H. Steven Wiley, Ph. D.
Director, Biomolecular Systems
Expertise
Dr. H. Steven Wiley, Director
Dr. H. Steven Wiley joined PNNL in 2000 as Director of the Biomolecular Systems Initiative (BSI). The BSI is a multidisciplinary program to understand complex biological systems from a systems perspective. As Director, Dr. Wiley is building a program to use PNNL's unique capabilities in cell imaging, computational biology and high-throughput proteomics to understand cell communication.
Dr. Wiley's research interests have focused on understanding mechanisms of cell communication and signaling using the epidermal growth factor receptor (EGFR) system as a model. He pioneered methods for the quantitative analysis of receptor dynamics in mammalian cells and published some of the first computer models of receptor regulation. He has been a major contributor to the field of receptor research, particularly with regard to the control of receptor distribution within cells.
More recently, his work has focused on understanding the control of growth factor activity at the cell surface as a way to control the growth of both normal and cancer cells. Dr. Wiley's work is notable for combining the techniques of molecular and cellular biology with both biochemical and optical assays. The results are then used to build computer models of the underlying cellular processes.
Experience
Dr. Wiley joined the University of Utah, Department of Pathology as an Assistant Professor in 1982, became an Associate Professor in 1989, and a Professor in 1995. At the university, he was head of the departmental graduate program and served as a thesis advisor, postdoctoral advisor, and fellowship advisor. He developed several courses, including "Scientific Applications of Microcomputers," "Analytical and Preparative Techniques in Cellular Biochemistry," "Molecular Biology of Cancer and Growth Control," and "Digital Cell Imaging."
In addition, Dr. Wiley has been an external reviewer for the National Science Foundation and the Veterans Administration. He was a special study section member of the National Cancer Institute, a member of NASA Life Sciences cell physiology study section, and a member of the International and Cooperative Projects study section for the National Institute of Health. From 1995 to 1997, Dr. Wiley served on the Scientific Advisory Board of Cellink, Inc. in Salt Lake City, and Entelos, Inc., Menlo Park, Califorina. He has also been a consultant for Bio-Rad Laboratories and Genta, Inc.
Dr. Wiley is author or co-author of more than 130 scientific publications, including more than 70 articles in peer-reviewed scientific journals and 10 review articles and book chapters. He has also written five commercial graphics and data analysis software packages. Dr. Wiley has served as a reviewer for more than 20 scientific journals, including the American Journal of Physiology, Analytical Biochemistry, Biochimica et Biophysica Acta, Cancer Research, Cell Regulation, Journal of Biological Chemistry, Journal of Cell Biology, Journal of Cellular Biochemistry, Journal of Cell Science, and Nature.
Education
- Postdoc., Cell Biology, University of California, 1979-1982
- Ph.D., Biochemistry/Cell Biology, University of Tennessee-Oak Ridge School of Biomedical Sciences, 1979
- B.S., Biology, University of Tennessee-Knoxville, 1974
Professional Societies
- American Society for Cell Biology
- American Society for Biochemistry and Molecular Biology
- American Association for Cancer Research
- American Association for the Advancement of Science
Selected Publications
Wiley, H.S. (2006) Systems Biology. The Scientist, 20(6), 53-57.
Dong, J.Y., Opresko, L.K., Chrisler, W.B., Orr, G., Quesenberry, R.A., Lauffenburger, D.A. and Wiley, H.S. (2005). "The Membrane-anchoring Domain of EGF receptor Ligands Restrict Their Ability to Operate in Juxtacrine Mode." Mol. Bio. Cell 16, 2984-2998.
Chen, W. N., Woodbury, R. L., Kathmann, L. E., Opresko, L. K., Zangar, R. C., Wiley, H. S., and Thrall, B. D. (2004). "Induced Autocrine Signaling through the Epidermal Growth Factor Receptor Contributes to the Response of Mammary Epithelial Cells to Tumor Necrosis Factor alpha." J. Biol. Chem. 279, 18488-18496.
Wiley, H.S., Shvartsman, S.Y., and Lauffenburger, D.A. (2003). "Computational Modeling of the EGF Receptor System: A Paradigm for Systems Biology." Trends Cell Biol. 13, 43-50.
Wiley, H.S. (2003). "Trafficking of the ErbB receptors and its influence on signaling." Exp. Cell Res. 284, 79-88.