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Josh Adkins to Participate in Keck Futures Initiative Conference

Dr. Joshua Adkins

Congratulations to systems biologist Dr. Joshua Adkins, Pacific Northwest National Laboratory, who is one of three PNNL scientists invited to participate in the ninth annual National Academies Keck Futures Initiative Conference, November 10-13 in Irvine, CA. The conference brings together the country's leading researchers in diverse scientific fields to jointly tackle a complex, pressing problem with a multidisciplinary approach.

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Systems Biology at Pacific Northwest National Laboratory

Systems biology at PNNL is focused on understanding gene and protein networks involved in individual cell signaling, communication between cells in communities, and cellular metabolic pathways. Our systems biology research program is driven by programs in the Fundamental & Computational Sciences Directorate (FCSD) and EMSL, a national user facility located at PNNL, as well as by collaborations with researchers around the world.

Not only are these capabilities being applied to problems of national/international importance, but they are available to outside users.

Talented Multidisciplinary Teams

The integrated talents of our multidisciplinary research teams lend strength to our systems biology research. Our biologists, microscopy experts, and proteomicists study the thousands of proteins and/or other cellular components, which are regulated through variations in their location, their activity, and their state of modification. Our bioinformaticists and computational biologists 1) work with bench scientists to integrate high-throughput instruments into a computational infrastructure; (2) create models of cellular networks appropriate for inferring the structure and function of cellular networks from large volumes high-throughput, heterogeneous data; and (3) develop software to aid visualization and interpretation of this flood of data.

The methods we are developing to integrate and interpret high-throughput, quantitative data will serve as a foundation for creating predictive models of cellular responses and functions.

A Strong Technical Infrastructure

Advanced instrumentation and technologies at both PNNL and EMSL provide a strong technical infrastructure for our systems biology research. We combine world-class

  • High-throughput proteomic tools
  • Sequencing technologies
  • Precise analytical methods
  • Multimodal imaging capabilities
  • Sophisticated computational tools

Applying Systems Biology to Problems of National Interest

We apply our systems biology methods to and enhance our systems biology capabilities through a variety of research areas, including cellular responses to oxidative stress and radiation, interrogative cell signaling, network biology, cellular responses to environmental stress, biomarkers that indicate environmental contaminants and disease, biofilms, and microbial communities.

Through our research, we address problems important to the U.S. Department of Energy and the nation, including clean energy production, carbon sequestration, environmental cleanup, improved disease diagnosis and treatment, and protecting people from environmental hazards.

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