Print This PageRichard D. Smith, Ph.D.
Richard Smith
Current Activities and Projects
Dr. Smith's research has involved the development and application of advanced analytical methods and instrumentation, with particular emphasis on high resolution separations and mass spectrometry, and their applications in biological and biomedical research. Much of his research over the last 15 years has focused on the development and application of new ultra-sensitive and comprehensive methods for quantitatively probing the entire array of proteins expressed by a cell, tissue or organism, i.e., their "proteomes". Current interests also include greatlyincreasing the throughput and sensitivity of proteomics and metabolomics measurements to meet the needs systems biology research.
Dr. Smith is an adjunct faculty member of the Department of Chemistry, Washington State University , and the Department of Chemistry, University of Utah, and an affiliate faculty member of the Department of Chemistry, University of Idaho. He has presented more than 350 invited or plenary lectures at national and international scientific meetings, and is the author or co-author of more than 575 publications. Dr. Smith holds twenty seven patents and has been the recipient of seven R&D 100 Awards. He is Director of the NIH Research Resource for Integrative Proteomics located at PNNL.
Education
- Ph.D., Physical Chemistry, University of Utah, 1975
- B.Sc., Chemistry, Lowell Technological Institute, 1971
Honors and Awards
- 2003 American Chemical Society Award for Analytical Chemistry
- R&D 100 Award for development of automated capillary LC-FTICR MS instrumentation (2003)
- Induction to Battelle’s Distinguished Inventors (2003)
- ICI list of most cited chemists, the DOE Energy 100 Award (2000)
- PNNL Mentor of the Year (2000)
- Battelle Inventor of the Year (2000)
- R&D 100 Award for development of the Electrodynamic Ion Funnel (1999)
- R&D 100 Awards for development of MICLEAN/MICAE Process (1998)
- R&D 100 Awards for development of Microdialyzer (1998)
Professional Affiliations
- American Chemical Society
- American Society of Mass Spectrometry
- American Assoication for the Advancement of Science
- Protein Society
Selected Publications
Y. Shen, J. Kim, E. F. Strittmatter, Jon M. Jacobs, D. G. Camp II, R. Fang, N. Tolić, R. J. Moore and R. D. Smith. 2005. “Characterization of the human blood plasma proteome.” Proteomics 5:4034-4045.
A. D. Norbeck, M. E. Monroe, K. K. Anderson, D. S. Daly, J. N. Adkins and R. D. Smith. 2005. “The utility of accurate mass and LC elution time information in the analysis of complex proteomes.” J. Amer. Soc. Mass Spectrom 16:1239-1249.
K. Tang, A.A. Shvartsburg, H.-N. Lee, D. C. Prior, M. A. Buschbach, F. Li, A. Tolmachev, G. A. Anderson and R. D. Smith. 2005. “High-sensitivity ion mobility spectrometry/mass spectrometry using electrodynamic ion funnel interfaces.” Anal. Chem.77:3330-3339.
J. M. Jacobs, J. N. Adkins, W.-J. Qian, T. Liu, Y. Shen, D. G. Camp II, and R. D. Smith. 2005. “Utilizing human blood plasma for proteomic biomarker discovery.” J. Proteome Res. 4:1073-1085.
E. Kolker, A. F. Picone, M. Y. Galperin, M. F. Romine, A. Osterman, K. S. Makarova, N. Kolker, R. Higdon, G. A. Anderson, D. Anderson, K. J. Auberry, G. Babnigg, Al. S. Beliaev, W. R. Cannon, T. Cherny, J. Cole, P. Edlefsen, D. A. Elias, Y. Gorby, L. J Hauser, K. Hixson, T. Holzman, J. Klappenbach, K. T. Konstantinidis, M. L. Land, M. S. Lipton, L. McCue, M. Monroe, R. Moore, H. Mottaz, L. Pasa-Tolic, G. Pinchuk, S. Purvine, X. Qiu, M. Serres, S. Tsapin, B. A. Zakrajsek, W. Zhu, J. Zhou, C. Lawrence, M. Riley, F. W. Larimer, R. Overbeek, F. R. Collart, J. R. Yates, III, R. D. Smith, C. Giometti, K. Nealson, J. K. Fredrickson and J. M. Tiedje. 2005. “Global profiling of Shewanella oneidensis MR-1: Expression of ‘hypothetical' henes and improved functional annotations.” Proc. Nat. Acad. Sci. 102:2099-2104.
