Diana J. Bigelow, Ph.D.
Experience
Diana Bigelow
Dr. Bigelow is well known for her studies of calcium regulation in heart and skeletal muscle and how it is affected by aging and oxidative stress. Her group also focuses on elucidation of fundamental molecular mechanisms of regulation of one calcium regulatory protein, the SR Ca-ATPase, by phospholamban.
Before coming to the Tri-Cities, Dr. Bigelow was an associate professor at the University of Kansas (Lawrence) where she directed research and taught since 1990. She also served as director of the Biochemistry and Biophysics group for the university's Department of Molecular Biosciences.
At PNNL, Dr. Bigelow is also the director of the new Systems Biology Fellows (SBF) program, which provides a unique postdoctoral training opportunity in multipdisciplinary research.
Education
- Postdoctoral, Biochemistry, University of Maryland, 1985-1990
- Ph.D., Biochemistry, University of Minnesota, 1985
- B.S. General Science, University of Iowa, 1975
Honors and Awards
- NIH Research Career Development Awardee (1996-2001)
- Editorial Board Member, Biophysical Journal (2000 - 2006)
- Member, NIH Chemistry & Biophysics Fellowship Panel (2003 - 2006)
- Member & Chair, NIH/NIA Biology of Aging Review Panel (1998-2002)
Selected Publications
Sacksteder, C.A., Qian, W.-J., Knyushko, T.V., Wang, H., Chin, M.H., Lacan, G., Melega, W.P., Camp, D.G. II, Smith, R.D., Smith, D.J., Squier, T.C., and Bigelow, D.J. (2006). "Endogenously Nitrated Proteins in Mouse Brain: Links To Neurodegenerative Disease," Biochemistry 45, 8009 - 8022.
Boschek, CB, Jones, TE, Smallwood, HS, Squier, TC, and Bigelow, DJ (2008). "Loss of Calmodulin-Dependent Inhibition of RyR1 Calcium Release Channel Upon Oxidation of Methionines in Calmodulin." Biochemistry 47, 131 - 142.
Qian, WJ and Bigelow, DJ (2008). "Quantitative Mapping of the Nitroproteome," (Invited Review) M. Enzymol. Nitric Oxide Part F: Oxidative and Nitrosative Stress in Redox Regulation of Cell Signaling 440, 191-205.
Bigelow, DJ (2009). "Nitrotyrosine Modification of SERCA2: A Cellular Sensor of Reactive Nitrogen Species." Pflugers Archiv: Eur. J. Physiol. 457, 701 - 710.
Chen, L.T.L., Yao, Q., Soares, T.A., Squier, T.C., and Bigelow, D.J. (2009). "Phospholamban modulates the functional coupling between nucleotide domains in Ca-ATPase Oligomeric complexes in cardiac sarcoplasmic reticulum." Biochemistry 48, 2411 - 2421.