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Print This PageDiana J. Bigelow, Ph.D.
Experience
Diana Bigelow
Dr. Bigelow is well known for her studies of calcium regulation in heart and skeletal muscle and how it is affected by aging and oxidative stress. Her group also focuses on elucidation of fundamental molecular mechanisms of regulation of one calcium regulatory protein, the SR Ca-ATPase, by phospholamban.
Before coming to the Tri-Cities, Dr. Bigelow was an associate professor at the University of Kansas (Lawrence) where she directed research and taught since 1990. She also served as director of the Biochemistry and Biophysics group for the university's Department of Molecular Biosciences. At PNNL, Dr. Bigelow is also the director of the new Systems Biology Fellows (SBF) program, which provides a unique postdoctoral training opportunity in multipdisciplinary research.
Education
- Postdoctoral, Biochemistry, University of Maryland, 1985-1990
- Ph.D., Biochemistry, University of Minnesota, 1985
- B.S. General Science, University of Iowa, 1975
Honors and Awards
- NIH Research Career Development Awardee (1996-2001)
- Editorial Board Member, Biophysical Journal (2000 - 2006)
- Member, NIH Chemistry & Biophysics Fellowship Panel (2003 - 2006)
- Member & Chair, NIH/NIA Biology of Aging Review Panel (1998-2002)
Selected Publications
Bigelow DJ and TC Squier. 2005. “Redox modulation of cellular signaling and metabolism through Reversible Oxidation of Methionine Sensors in Calcium Regulatory Proteins” Biochim. Biophys. Acta 1703(2):121-134.
Hulme JT, K Konoki, T Lin, MA Gritsenko, DG Camp, II, DJ Bigelow, and WA Catterall. 2005. "Sites of proteolytic processing and noncovalent association of the distal C-terminal domain of CaV1.1 channels in skeletal muscle.” Proceedings of the National Academy of Sciences of the United States of America 102(14):5274 -5279.
Li J, Boschek CB, Sacksteder CA, Xiong Y, Squie, TC and Bigelow DJ. "Essential Role for Pro21 in Phospholamban for Optimal Inhibition of the Ca-ATPase" Biochemistry (in press).
Knyushko TV, Sharov VS, Williams TD, Schöneich CS and Bigelow DJ. 2005. "3-Nitrotyrosine-Modification of SERCA2a in the Aging Heart: A Distinct Signature of Cellular Redox Environment." Biochemistry 44: 13071–13081.
Chen B, TC Squier, and DJ Bigelow. 2004. "Calcium activation of the Ca-ATPase enhances conformational heterogeneity between nucleotide binding and phosphorylation domains." Biochemistry 43(14):4366-4374.
