Research Supported by Public Sources
At Pacific Northwest National Laboratory (PNNL), we conduct research supported by both public sources and private Laboratory Research and Development. Grants from the public sector are received primarily from government agencies, such as the U.S. Department of Energy (DOE) and the National Institutes of Health (NIH).
U.S. Department of Energy
Genomics: GTL (Genomes to Life) Program
- Shewanella Federation
- Microbial Protein-Protein Interactions (MiPPI): Genomics:GTL Center for Molecular and Cellular Systems A joint project of Oak Ridge and Pacific Northwest National Laboratories
- Development and Application of New Technologies for Comprehensive and Quantitative High-Throughput Microbial Proteomics
- Development of Multipurpose Tags and Affinity Reagents for Rapid Isolation and Visualization of Protein Complexes
Low Dose Radiation Research Program
- Molecular Mechanisms Underlying Cellular Adaptive Response to Low Dose Radiation
- Mechanisms of Three-Dimensional Intercellular Signaling in Mammary Epithelial Cells in Response to Low Dose, Low Linear Energy Transfer (LET) Radiation: Implications for the Radiation-Induced Bystander Effect
- Molecular Energetics of Clustered Damage Sites
- Effects Of Low Doses of Radiation on DNA Repair
- Cell Transforming Bystander Signals
- Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation
- Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation
Environmental Remediation Sciences Program
- Biomolecular Mechanisms Controlling Metal and Radionuclide Transformations in Anaeromyxobacter dehalogenans
- Anaerobic Biotransformation and Mobility of Pu and of Pu-EDTA
- Biogeochemical Processes Controlling Microbial Reductive Precipitation of Radionuclides
- Parallel Proteomic Identification of Metal Reductases and Determination of Their Relative Abundance in a Series of Metal-Reducing Microbes
National Institutes of Health
National Cancer Institute
- Proteomic Identification of NAF Biomarkers
- High-Throughput Evaluation of Breast Cancer Markers
- Development of Antibody Microarrays for the National Cancer Institute Early Detection Research Network
- High Dynamic Range Quantitative Proteomic Profiling of Plasma Samples from Pre-diagnostic Colon Cancer Patients and Controls
National Center for Research Resource
National Heart, Lung, and Blood Institute
- 3-D Imaging and Computer Model of the Respiratory Tract
- Regulation of Calcium Transport in Cardiac Muscle
- 3-D Imaging and Computer Model of the Respiratory Tract
National Human Genome Research Institute
National Institute of Aging
- Structural Basis – Altered Calcium Homeostatis of Aging
- 3-Nitrotyrosine in Aging of Skeletal Muscle and Heart
National Institute of Allergy and Infectious Disease
- Pseudomonas aeruginosa Outer Membrane Protein Modeling
- Identifying Targets for Therapeutic Interventions of Salmonella Bacteria and Orthopox Viruses Using Proteomic Technology
National Institute of Biomedical Imaging and Bioengineering
National Institute of Diabetes and Digestive and Kidney Diseases
- Proteomics and Metabolomics Studies of Type 1 Diabetes
- Advanced Proteomics and Metabolomics: Type 2 Diabetes and Pre-Diabetes
National Institute on Drug Abuse
National Institute of General Medical Sciences
- Modeling Cell Receptor Signaling Pathways
- Metal Ion Probes Membrane Protein Structure and Function
- High-Throughput Proteomics for Trauma Research with the Inflammation and the Host Response to Injury Consortium
- Pseudomonas aeruginosa Outer Membrane Protein Modeling
