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Richard C. Zangar, Ph.D.


Richard Zangar
Richard Zangar

Dr. Zangar's research is directed towards finding biomarkers for human diseases, with an emphasis on breast cancer, pulmonary disease, and oxidative stress. This work encompassed applied biomarker discovery and validation studies, as well as fundamental studies directed towards understanding the underlying molecular processes involved in biomarker release from cells.


Dr. Zangar is a principal investigator on several projects from the National Cancer Institute and internal Laboratory Directed Research and Development. He has served as a peer-reviewer for a variety of journals, including the Journal of Pharmacology and Experimental Therapeutics, Drug Metabolism and Disposition, the Journal of Proteome Research, Toxicology and Applied Pharmacology, Current Opinions in Molecular Therapeutics, and others. He has authored 44 publications.


  • Ph.D., Toxicology, Oregon State University, 1992
  • M.S., Biology, Washington State University, 1986
  • B.S., Environmental Science, Western Washington University, 1982

Professional Affiliations

  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology
  • American Society for Pharmacology and Experimental Therapeutics
  • Proteome Society
  • Society of Toxicology

Selected Publications

Zangar RC, SM Varnum, and N Bollinger. 2005. "Studying cellular processes and detecting disease with protein microarrays. Drug Metabolism Reviews.

Daly DS, AM White, SM Varnum, KK Anderson, and RC Zangar. 2005. "Evaluating concentration estimation errors in ELISA microarray experiments." BMC Bioinformatics 6, 17 (pp. 1-11).

Chen WU, RL Woodbury, LK Opresko, RC Zangar, HS Wiley, and BD Thrall. 2004. "Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor α." Journal of Biological Chemistry 279(18):18488-18496.

Varnum SM, Woodbury RL, and Zangar RC. 2004. "A Protein Microarray ELISA for Screening Biological Fluids." In: Meth. Mol. Biol., Protein Arrays: Methods and Protocols. (E. Fung, Ed.) 278:161-172.

Zangar RC, DR Davydov, and S Verma. 2004. "Regulatory mechanisms that control the production of reactive oxygen species by cytochromes P450." Toxicol. Appl. Pharmacol.

Contact Information

Systems Biology at PNNL

Research & Capabilities