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Thomas J. Weber, Ph.D.


Thomas Weber
Thomas Weber

Primary research interests include defining the biological effects of low doses of radiation, defining transcriptional regulation of wound healing and carcinogenesis and the molecular switches that govern reversibility in these processes.


  • Ph.D., Toxicology, Texas A&M University, 1994
  • B.S., Biology, University of Wisconsin, 1987

Selected Publications

Weber TJ, LK Opresko, GJ Waisman Newton, RD Quesenberry, N Bollinger, RJ Moore, and RD Smith. 2009. "Regulation of the Low Dose Radiation Paracrine-Specific Anchorage-Independent Growth Response by Annexin A2." Rad Res. (in press).

Sweeney LM, KD Thrall, TS Poet, RA Corley, TJ Weber, BJ Locey, J Clarkson, S Sager, and ML Gargas. 2008. "Physiologically based pharmacokinetic modeling of 1,4-dioxane in rats, mice, and humans." Toxicol Sci. 101(1):32-50.

Dutta D, SK Sundaram, JG Teeguarden, BJ Riley, LS Fifield JM Jacobs, SR Addleman, GA Kaysen, BM Moudgil, and TJ Weber. 2007. "Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials." Toxicol Sci. 100(1):303-15.

Weber TJ, HS Smallwood, LE Kathmann, LM Markillie, TC Squier, and BD Thrall. 2006. "Functional Linkage Between Tumor Necrosis Factor Biosynthesis and Calmodulin-Dependent Activation of iNOS in RAW 264.7 Macrophages." Am J Physiol Cell Physiol. 290(6):C1512-20.

Weber TJ, RW Siegel, LM Markillie, WB Chrisler, XC Lei, and NH Colburn. 2005. "A paracrine signal mediates the cell transformation response to low dose gamma radiation in JB6 cells." Mol Carcinog. 43(1):31-7.

Contact Information

Systems Biology at PNNL

Research & Capabilities