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Thomas J. Weber, Ph.D.

Expertise

Thomas Weber
Thomas Weber

Primary research interests include identifying the intersection between effective wound repair and carcinogenesis with emphasis on deciphering the molecular basis of anchorage-independent growth and the molecular switches that govern reversibility in these processes. Additional interests include new frontiers in protein kinase regulation with a focus on oscillatory behavior of protein kinases. He has authored 25 peer-reviewed publications.

Education

  • Ph.D., Toxicology, Texas A&M University, 1994
  • B.S., Biology, University of Wisconsin, 1987

Honors and Awards

  • 1986, 1987 Honors, University of Wisconsin-Oshkosh.
  • 1987 Lesley Allen Fellowship Award in Biology, University of Wisconsin-Oshkosh.
  • 1992 Second Place, Gulf Coast Society of Toxicology, Platform Presentation.
  • 1992 Travel Award, Society of Toxicology.
  • 1994 McDonalds Award for Excellence in Teaching by Graduate Students, Texas A&M University.
  • 1994 Honorable Mention, Society of Toxicology, Mechanisms Specialty Section Award.
  • 1994 Cellular Toxicology Student Award, 1994 Congress on Cell and Tissue Culture, Tissue Culture Association.
  • 1994 NIEHS Postdoctoral Fellow, Faculty of Toxicology, The University of Texas at Austin.
  • 1995 Honorable Mention, Society of Toxicology, Molecular Biology Specialty Section Award.

Selected Publications

Weber TJ, S Negash, HS Smallwood, KS Ramos, BD Thrall, and TC Squier. 2004. "Calmodulin Involvement in Stress-Activated Nuclear Localization of Albumin in JB6 Epithelial Cells." Biochemistry 43(23):7443-50.

Weber TJ and LM Markillie. 2003. "Regulation of Activator Protein-1 (AP-1) by 8-iso-PGE2 in a Thromboxane A2 Receptor-Dependent and -Independent Manner." Molecular Pharmacology 63(5):1075-1081.

Suzukawa K, TJ Weber, and NH Colburn. 2002. "AP-1, NF-κB, and Erk Activation Thresholds for Promotion of Neoplastic Transformation in the Mouse Epidermal JB6 Model." Environ. Health Persp. 110:865-870.

Weber TJ, LM Markillie, WB Chrisler, G Vielhauer, and JW Regan. 2002. "Modulation of Clonal Selection Processes by the Prostaglandin F2α Receptor." Molecular Carcinogenesis 35(4):163-172.

Weber TJ, Q Huang, TJ Monks, and SS Lau. 2001. "Differential Regulation of Redox Responsive Transcription Factors by the Nephrocarcinogen 2,3,5-(trisglutathion-S-yl)hydroquinone." Chemical Research in Toxicology 14(7):814-821.

Contact Information

Systems Biology at PNNL

Research & Capabilities

Resources