Thomas J. Weber, Ph.D.
Expertise
Thomas Weber
Primary research interests include defining the biological effects of low doses of radiation, defining transcriptional regulation of wound healing and carcinogenesis and the molecular switches that govern reversibility in these processes.
Education
- Ph.D., Toxicology, Texas A&M University, 1994
- B.S., Biology, University of Wisconsin, 1987
Selected Publications
Weber TJ, Opresko LK, Waisman Newton GJ, Quesenberry RD, Bollinger N, Moore RJ and Smith RD. 2009. "Regulation of the Low Dose Radiation Paracrine-Specific Anchorage-Independent Growth Response by Annexin A2." Rad Res. (in press).
Sweeney LM, Thrall KD, Poet TS, Corley RA, Weber TJ, Locey BJ, Clarkson J, Sager S, Gargas ML. 2008. "Physiologically based pharmacokinetic modeling of 1,4-dioxane in rats, mice, and humans." Toxicol Sci. 101(1):32-50.
Dutta D, Sundaram SK, Teeguarden JG, Riley BJ, Fifield LS, Jacobs JM, Addleman SR, Kaysen GA, Moudgil BM, Weber TJ. 2007. "Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials." Toxicol Sci. 100(1):303-15.
Weber TJ, Smallwood HS, Kathmann LE, Markillie LM, Squier TC, Thrall BD. 2006. "Functional Linkage Between Tumor Necrosis Factor Biosynthesis and Calmodulin-Dependent Activation of iNOS in RAW 264.7 Macrophages." Am J Physiol Cell Physiol. 290(6):C1512-20.
Weber TJ, Siegel RW, Markillie LM, Chrisler WB, Lei XC., Colburn NH. 2005. "A paracrine signal mediates the cell transformation response to low dose gamma radiation in JB6 cells." Mol Carcinog. 43(1):31-7.
Weber TJ, S Negash, HS Smallwood, KS Ramos, BD Thrall, and TC Squier. 2004. "Calmodulin Involvement in Stress-Activated Nuclear Localization of Albumin in JB6 Epithelial Cells." Biochemistry 43(23):7443-50.
Weber TJ and LM Markillie. 2003. "Regulation of Activator Protein-1 (AP-1) by 8-iso-PGE2 in a Thromboxane A2 Receptor-Dependent and -Independent Manner." Molecular Pharmacology 63(5):1075-1081.
Suzukawa K, TJ Weber, and NH Colburn. 2002. "AP-1, NF-kB, and Erk Activation Thresholds for Promotion of Neoplastic Transformation in the Mouse Epidermal JB6 Model." Environ. Health Persp. 110:865-870.
Weber TJ, LM Markillie, WB Chrisler, G Vielhauer, and JW Regan. 2002. "Modulation of Clonal Selection Processes by the Prostaglandin F2α Receptor." Molecular Carcinogenesis 35(4):163-172.
Weber TJ, Q Huang, TJ Monks, and SS Lau. 2001. "Differential Regulation of Redox Responsive Transcription Factors by the Nephrocarcinogen 2,3,5-(trisglutathion-S-yl)hydroquinone." Chemical Research in Toxicology 14(7):814-821.