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Brian D. Thrall, Ph.D.


Brian Thrall
Brian Thrall

Dr. Thrall's research focuses on understanding the mechanisms in which changes in the extracellular environment modulate cell signaling pathways to influence the balance between cell proliferation and cell death. Current research projects are employing genomic and proteomic strategies to investigate the molecular mechanisms of cross-regulation between growth factor and stress signaling pathways, using mammary epithelial cells and macrophages as model systems. Ultimately, the goal of these studies is to provide a better understanding of how information processing through divergent signaling pathways is coordinately regulated to maintain homeostasis, and why these homeostatic mechanisms break down during disease.


In addition to primary role as Technical Group Leader for the Cell Biology Group at PNNL, he holds adjunct positions in the Graduate Research Program at Washington State University and regularly serves as a peer reviewer for a variety of publications, including the Journal of Biology and Chemistry, Toxicology and Applied Pharmacology, Differentiation, Oncogene, and Toxicological Sciences. In addition, Dr. Thrall has served on several special emphasis review panels for the National Institutes of Health in the area of proteomic and genomic analysis of cancer, as well as a proposal reviewer for the Department of Energy, U.S. Air Force Office of Scientific Research and the Department of State. He has authored or co-authored over 50 peer-reviewed publications.


  • Ph.D., Pharmacology, Washington State University, 1990
  • M.A., Biology, University of South Dakota, 1985
  • B.S., Biology, University of South Dakota, 1983

Honors and Awards

  • Society of Toxicology Board of Publications Award for the "Best Paper" in Toxicology and Applied Pharmacology, 2001
  • President, Pacific Northwest Association of Toxicologists, 2000-2001
  • Washington State University Graduate Research Travel Award, 1990
  • American Society for Pharmacology and Experimental Therapeutics Graduate Award, 1988

Professional Affiliations

  • American Society for Cell Biology
  • Society of Toxicology, Molecular Biology Specialty Section
  • Pacific Northwest Association of Toxicologist

Selected Publications

Chen W-NU, RL Woodbury, RC Zangar, LE Kathmann, LK Opresko, HS Wiley, and BD Thrall. 2004. "Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor α." Journal of Biological Chemistry 279(18):18488-18496.

Jacobs JM, L-R Rong, HM Mottaz, DJ Anderson, RJ Moore, W-NU Chen, KJ Auberry, EF Strittmatter, ME Monroe, BD Thrall, DG Camp II, and RD Smith. 2004. "Multidimensional proteome analysis of human mammary epithelial cells." Journal of Proteome Research 3(1):68-75.

Weber TJ, S Negash, HS Smallwood, KS Ramos, BD Thrall, and TC Squier. 2004. "Calmodulin involvement in stress-activated nuclear localization of albumin in JB6 epithelial cells." Biochemistry 43(23):7443-7450.

Chen W-NU, L-R Yu, EF Strittmatter, BD Thrall, DG Camp II, and RD Smith. 2003. "Detection of in situ labeled cell surface proteins by mass spectrometry: application to the membrane subproteome of human mammary epithelial cells." Proteomics 3(8):1647-1651.

Holtom GR, SD Colson, and BD Thrall. 2002. "Locating molecules using optical microscopy: 3-D imaging by coherent anti-Stokes raman scattering." In Proceedings IEEE International Symposium on Biological Imaging. Pp. 781-784.

Contact Information

Systems Biology at PNNL

Research & Capabilities