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Keqi Tang, Ph.D.


Keqi Tang
Keqi Tang

Dr. Tang's research focuses on the development of advanced ion mobility spectrometry (IMS) instrumentation and methods for ultimate high throughput applications in system biology research. Current research projects include new technology development related to both conventional drift tube IMS and high field asymmetric waveform IMS (FAIMS) through extensive theoretical modeling and experimental evaluation. Other research efforts include mass spectrometry instrumentation with focus on the new ESI interface development and fundamentals of electrospray ionization.


  • Ph.D., Mechanical Engineering, Yale University, 1994
  • M.S. & M.Ph., Mechanical Engineering, Yale University, 1992
  • M.S., Engineering Thermophysics, University of Science and Technology of China, 1987
  • B.S., Mathematical Mechanics, Tsinghua University, 1983

Honors and Awards

  • Pacific Northwest National Laboratory Inventor of the Year, 2007
  • Battelle key contributor award, 2006
  • FLC (Federal Laboratory Consortium) Award for Excellence in Technology Transfer, 2004
  • Battelle key contributor award, 2004
  • Battelle key contributor award, 2003
  • US Department of Energy Postdoctoral Fellowship (06/1995 - 08/1996)
  • Yale University Graduate Fellowship (11/1989 - 12/1990)

Professional Affiliations

  • Member of American Society for Mass Spectrometry (1997 - Present)
  • Reviewer for Analytical Chemistry, Journal of the American Society for Mass Spectrometry, Journal of physical chemistry, Rapid Communications in Mass Spectrometry, Microfluidics and Nanofluidic, Journal of the Air & Waste Management Association.

Selected Publications

Kelly RT, JS Page, R Zhao, W Qian, HM Mottaz, K Tang, and RD Smith. 2008. "Capillary-Based Multi-Nanoelectrospray Emitters: Improvements in Ionization Transmission Efficiency and Implementation with Capillary Reversed-Phase LC-ESI-MS." Anal. Chem., 80, 143-149.

Livesay EA, K Tang, BK Taylor, MA Buschbach, DF Hopkins, BL LaMarche, R Zhao, Y Shen, DJ Orton, RJ Moore, RT Kelly, HR Udseth and RD Smith. 2008. "Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses." Anal. Chem., 80, 294-302.

Petyuk VA, N Jaitly, RJ Moore, J Ding, T Metz, K Tang, ME Monroe, AV Tolmachev, JN Adkins, ME Belov, AR Dabney, W Qian, DG Camp II, and RD Smith. 2008. "Elimination of Systematic Mass Measurement Errors in Liquid Chromatography-Mass Spectrometry Based Proteomics using Regression Models and a priori Partial Knowledge of the Sample Content." Anal. Chem., 80, 693-706.

Baker ES, K Tang, WF Danielson III, DC Prior, and RD Smith. 2008. "Simultaneous Fragmentation of Multiple Ions Using IMS Drift Time Dependent Collision Energies." J. Am Soc Mass Spectrom., 19, 411-419.

Page JS, K Tang, RT Kelly, and RD Smith. 2008. "Subambient Pressure Ionization with Nanoelectrospray Source and Interface for Improved Sensitivity in Mass Spectrometry." Anal. Chem., 80, 1800-1805.

Contact Information

Systems Biology at PNNL

Research & Capabilities