Keqi Tang, Ph.D.
Expertise
Keqi Tang
Dr. Tang's research focuses on the development of advanced ion mobility spectrometry (IMS) instrumentation and methods for ultimate high throughput applications in system biology research. Current research projects include new technology development related to both conventional drift tube IMS and high field asymmetric waveform IMS (FAIMS) through extensive theoretical modeling and experimental evaluation. Other research efforts include mass spectrometry instrumentation with focus on the new ESI interface development and fundamentals of electrospray ionization.
Education
- Ph.D., Mechanical Engineering, Yale University, 1994
- M.S. & M.Ph., Mechanical Engineering, Yale University, 1992
- M.S., Engineering Thermophysics, University of Science and Technology of China, 1987
- B.S., Mathematical Mechanics, Tsinghua University, 1983
Honors and Awards
- Pacific Northwest National Laboratory Inventor of the Year, 2007
- Battelle key contributor award, 2006
- FLC (Federal Laboratory Consortium) Award for Excellence in Technology Transfer, 2004
- Battelle key contributor award, 2004
- Battelle key contributor award, 2003
- US Department of Energy Postdoctoral Fellowship (06/1995 - 08/1996)
- Yale University Graduate Fellowship (11/1989 - 12/1990)
Professional Affiliations
- Member of American Society for Mass Spectrometry (1997 - Present)
- Reviewer for Analytical Chemistry, Journal of the American Society for Mass Spectrometry, Journal of physical chemistry, Rapid Communications in Mass Spectrometry, Microfluidics and Nanofluidic, Journal of the Air & Waste Management Association.
Selected Publications
R. T. Kelly, J. S. Page, R. Zhao, W. Qian, H. M. Mottaz, K. Tang and R. D. Smith, 2008. "Capillary-Based Multi-Nanoelectrospray Emitters: Improvements in Ionization Transmission Efficiency and Implementation with Capillary Reversed-Phase LC-ESI-MS." Anal. Chem., 80, 143-149.
E. A. Livesay, K. Tang, B. K. Taylor, M. A. Buschbach, D. F. Hopkins, B. L. LaMarche, R. Zhao, Y. Shen, D. J. Orton, R. J. Moore, R. T. Kelly, H. R. Udseth and R. D. Smith, 2008. "Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses." Anal. Chem., 80, 294-302.
V. A. Petyuk, N. Jaitly, R. J. Moore, J. Ding, T. Metz, K. Tang, M. E. Monroe, A. V. Tolmachev, J. N. Adkins, M. E. Belov, A. R. Dabney, W. Qian, D. G. Camp, II, and R. D. Smith, 2008. "Elimination of Systematic Mass Measurement Errors in Liquid Chromatography-Mass Spectrometry Based Proteomics using Regression Models and a priori Partial Knowledge of the Sample Content." Anal. Chem., 80, 693-706.
E. S. Baker, K. Tang, W. F. Danielson III, D. C. Prior, and R. D. Smith, 2008. "Simultaneous Fragmentation of Multiple Ions Using IMS Drift Time Dependent Collision Energies." J. Am Soc Mass Spectrom., 19, 411-419.
J. S. Page, K. Tang, R. T. Kelly and R. D. Smith, 2008. "Subambient Pressure Ionization with Nanoelectrospray Source and Interface for Improved Sensitivity in Mass Spectrometry." Anal. Chem., 80, 1800-1805.
T. Metz, J. S. Page, E. M. Baker, K. Tang, J. Ding, Y. Shen, and R. D. Smith, 2008. "High-Resolution Separations and Improved Ion Production and Transmission in Metabolomics." Trends in Anal. Chem., 27, 205-214.
R. T. Kelly, K. Tang, D. Irimia, M. Toner and R. D. Smith, 2008. "Simple PDMS Microchip Electrospray Emitter for Stable Cone-Jet Mode Operation in the Nano-Flow Regime." Anal. Chem., 80, 3824-3831.
R. T. Kelly, J. S. Page, I. Marginean, K. Tang and R. D. Smith, 2008. "Nanoelectrospray Emitter Arrays Providing Inter-Emitter Electric Field Uniformity." Anal. Chem., 80, 5660-5665.
I. Marginean, R. T. Kelly, D. C. Prior, B. L. Lamarche, K. Tang, and R. D. Smith, 2008. "Analytical characterization of the electrospray ion source in the low-flow regime." Anal. Chem., 80, 6573-6579.
E. W. Robinson, A. A. Shvartsburg, K. Tang, and R. D. Smith, 2008. "Resolving confounding effects of FAIMS dispersion voltage and electrode temperature on protein conformation analysis." Anal. Chem., 80, 7508-7515.