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David L. Stenoien, Ph.D


David Stenoien
David Stenoien

Dr. Stenoien's research interests includes the study of live-cell imaging of bioluminescent proteins in multiple dimensions and wavelengths. Spatial and temporal changes in protein distribution and mobility provide important clues about protein function and cell regulation that can aid in modeling signaling networks. With this in mind, we are developing the necessary reagents and imaging techniques to study the mechanisms of signaling pathway regulation and the effects of oxidative stress on these pathways.


  • Postdoctoral, Molecular and Cellular Biology, Baylor College of Medicine, 1997-2001
  • Ph.D., Molecular Biophysics, UT Southwestern Medical Center, 1996
  • BS, Biology, Trinity University, 1984

Honors and Awards

  • NIH Post-Doctoral Training Grant, 1998-2001
  • Quest Diagnostics Young Investigator Travel Award, 2000
  • ASCB Travel Grant , 1995
  • ASCB Travel Grant, 1993
  • NIH Predoctoral Training Grant in Biophysics, 1991-1994

Selected Publications

Sasai K, Katayama H, Stenoie, DL, Fujii S, Kimura M, Okano Y, Tatsuka M, Suzuki F, Earnshaw WC, Brinkley WR, and Sen S. 2004. "Aurora-C is a novel chromosomal passenger protein that can complement Aurora-B function in mitotic cells." Cell Motil. and Cytoskel. 59, 249-63.

Cushman* I, Stenoien* DL, and Moore MS. 2004. "Intranuclear dynamics of the Ran guanine nucleotide exchange factor, RCC1 are dependent upon the cell cycle, ATP and Ran levels." Mol. Biol. Cell. 15:245-255. (*Co-first authors.)

Stenoien DL, Sen S, Mancini MA, and Brinkley BR. 2003. "Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle." Cell Motil. Cytoskeleton 55:134-146.

Stenoien DL, Mielke M, and Mancini MA. 2002. "FRAP reveals that intranuclear ataxin-1 inclusions contain both fast and slow-exchanging components." Nature Cell Biol. 4:806-810.

Stenoien DL, Patel K, Mancini MG, Smith CL, O’Malley BW, and Mancini MA. 2001. "FRAP reveals estrogen receptor-α mobility is ligand- and proteasome-dependent." Nature Cell Biol. 3:15-23.

Contact Information

Systems Biology at PNNL

Research & Capabilities