David L. Springer, Ph.D.
Expertise
David Springer
- Proteomics and mass spectrometry
- Membrane and shed proteins involvement in tumor progression
- Bystander effects and genomic instability after radiation exposure
Experience
Dr. Springer joined Pacific Northwest National Laboratory in 1979 as a Research Scientist, became a Senior Research Scientist in 1983, and a Staff Scientist in 1989. Dr. Springer has been a principal investigator on many projects at Pacific Northwest National Laboratory funded by the Department of Energy, National Institutes of Health, the Environmental Protection Agency and private sponsors. He has served on review panels for the Department of Energy, National Institutes of Health and the Electric Power Research Institute. He has served as a peer-reviewer for a variety of journals, including Journal of Biological Chemistry, Journal of Toxicology and Pharmacology, Fundamental and Applied Toxicology. He has authored and co-authored over 70 scientific publications including over 40 peer-reviewed journals. He is currently an Adjunct Associate Professor of the Toxicology Graduate Faculty at Washington State University. Prior to joining Pacific Northwest National Laboratory in 1979, Dr. Springer was a research associate at Oregon State University studying the biochemical mechanisms responsible for adverse effects from rocket fuels and pyrrolizidine alkaloids.
Education
- Diplomat of American Board of Toxicology, 1980-present
- Postdoc., Biochemical Toxicology, Oregon State University, 1974-1979
- Ph.D., Biochemistry, Unversity of Idaho, 1974
- B.S., General Studies-Chemistry/Biology, 1970
Honors
- PNNL-Chester Cooper Mentor of the year award for Postdocs and Students, 2002
Professional Societies
- American Chemical Society
- Society of Toxicology
- Pacific Northwest Association of Toxicologists
- American Association for the Advancement of Science
Selected Publications
Ahram M, JN Adkins, DL Auberry, DS Wunschel, and DL Springer. 2004. "A proteomic approach to characterize shed proteins." Proteomics.
Springer DL, DL Auberry, M Ahram, JN Adkins, DS Wunschel, JM Feldhaus, JH Wahl, and KD Rodland. 2004. "Characterization of plasma membrane proteins from ovarian cancer cells using mass spectrometry." Disease Markers 19, 219-228.
Adkins JN, SM Varnum, KJ Auberry, RJ Moore, NH Angell, RD Smith, DL Springer, and JG Pounds. 2002. "Toward a human blood serum proteome: Analysis by multidimensional separation coupled with mass spectrometry." Molecular and Cellular Proteomics. MCP 1(12):947-955.
Liu Z, DB Mann, C Suquet, DL Springer, and MJ Smerdon. 2000. "Ultraviolet Damage and nucleosome folding of the 5S ribosomal RNA gene." Biochemistry 39(3):557-566.
Zangar RC, J Benson, VL Burnett, and DL Springer. 2000. "Cytochrome CYP2E1 is the primary catalyst for low-dose carbon tetrachloride metabolism in human liver microsomes." Chemico-Biological Interactions 125(3):233-243.