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Heidi J. Sofia, Ph.D.

Expertise

Heidi Sofia
Heidi Sofia

Primary interests are using sophisticated bioinformatics tools for discovery research in biology and in developing problem solving environments using visual and computational approaches.

Education

Honors and Awards

Professional Affiliations

Selected Publications

Korner H, HJ Sofia, and WG Zumft. 2003. "Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs." FEMS Microbiology Reviews 27(5):559-592.

Kajkowski EM, CF Lo, X Ning, S Walker, HJ Sofia, W Wang, W Edris, P Chandra, E Wagner, S Vile, K Ryan, B McHendry-Rinde, SC Smith, A Wood, KJ Rhodes, JD Kennedy, J Bard, JS Jacobsen, and BA Ozenberger. 2001. "Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module." J. Biol. Chem. 276(22):18748-18756.

Sofia HJ, G Chen, BG Hetzler, JF Reyes-Spindola, and NE Miller. 2001. "Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: Discovery and functional characterization using new analysis and information visualization methods." Nucleic Acids Research 29(5):1097-1106.

Saffer JD, CL Albright, AJ Calapristi, G Chen, VL Crow, SD Decker, KM Groch, SL Havre, JM Malard, TJ Martin, NE Miller, PJ Monroen, LT Nowell, DA Payne, JF Reyes Spindola, RE Scarberry, HJ Sofia, LC Stillwell, GS Thomas, SJ Thurston, LK Williams, and SJ Zabriskie. 2001. "Visualization and Integrated Data Mining of Disparate Information." Chemical Data Analysis in the Large: The Challenge of the Automation Age, Proceedings of the Beilstein-Institut International Workshop, May 22-26, 2000, Bozen, Italy , ed. MG Hicks. Beilstein-Institut, Frankfurt am Main, Germany.

Burland V, Y Shao, NT Perna, G Plunkett, HJ Sofia, and FR Blattner. 1998. "The complete DNA sequence and analysis of the large virulence plasmid of Escherichia coli O157:H7." Nucleic Acids Research 26(18):4196-204.

Contact Information

Heidi.Sofia@pnl.gov