Harish Shankaran, Ph.D.
Expertise
Harish Shankaran
Dr. Shankaran is a biomedical engineer with expertise in the computational modeling of biological systems. His research involves the application of tools and techniques from the engineering sciences — specifically from the areas of nonlinear dynamics, control systems theory, biochemical systems theory, optimization, parametric sensitivity analysis and image processing — to gain a systems level understanding of signal transduction networks. In addition to modeling and simulation of biomolecular network dynamics, Dr. Shankaran is interested in the development of tools to deduce network structure using data from high throughput experiments. He is the author of several publications in the areas of biophysics and computational biology.
Education
- Postdoctoral, Computational Biology & Informatics Group, Pacific Northwest National Laboratory, 2003-2006
- Ph.D., Chemical & Biological Engineering, State University of New York at Buffalo, 2003
- B.Tech (Honors), Chemical Engineering, Indian Institute of Technology, Kharagpur, India, 1997
Honors and Awards
- Biomedical Engineering Society (BMES) Award for Outstanding Scientific and Engineering Innovation in a Poster Presentation, BMES Annual Conference, Philadelphia, PA — 2004
Professional Affiliations
- Reviewer for BMC Systems Biology, BMC Bioinformatics, Annals of Biomedical Engineering, Journal of Controlled Release, Biorheology.
Selected Publications
Zhang, Y., Shankaran, H., Opresko, L., and Resat, H. (2008) "System theoretical investigation of HER mediated signaling." IET Systems Biology. 2: 273-284.
Shankaran, H., Zhang, Y., Opresko, L., and Resat, H. (2008) "Quantifying the effects of EGFR-HER2 co-expression on HER activation and trafficking." Biochem Biophys Res Commun. 371: 220-224.
Shankaran, H., Wiley, H. S., and Resat H. (2007) "Receptor downregulation and desensitization enhance the information processing ability of signaling receptors." BMC Systems Biology, Nov 9, 1:48.
Shankaran, H., Wiley, H. S., and Resat, H. (2007). "Cell surface receptors for signal transduction and ligand transport: A design principles study." PLoS Computational Biology, 3: e101.
Shankaran, H., Wiley, H. S., and Resat, H. (2006). "Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response." Biophys J 90: 3993-4009.