Jon Jacobs, Ph.D.
Expertise
Jon Jacobs
Dr. Jacobs' research expertise is in the application of proteomic technologies in the study of both prokaryotic and eukaryotic systems to obtain global quantitative measurements of protein abundance. Specifically, by using high efficiency liquid separations coupled with sensitive mass spectrometry, a more in-depth proteomic characterization of the model system can be obtained. Current applications include clinical proteomics with the study of cirrhosis progression using human liver biopsy samples from hepatitis C virus infected individuals as well as efforts to characterization protein secretion pathways by targeting the extracellular/secreted proteome of multiple human cell lines. In addition to being a Senior Scientist at PNNL, Dr. Jacobs also serves as an adjunct faculty member at Washington State University Tri-Cities.
Education
- Ph.D. , Biochemistry, Montana State University, 2002
- B.S., Biochemistry, Brigham Young University, 1996
Selected Publications
"High sensitivity proteomics assisted discovery of a novel operon involved in the assembly of photosystem II, a membrane protein complex." Wegener, K.M., Welsh, E.A., Thornton, L.E., Keren, N., Jacobs, J.M., Hixson, K.K., Monroe, M.E., Camp, D.G. 2nd, Smith, R.D., Pakrasi, H.B. (2008) J Biol Chem. 283: 27829-27837.
"The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle." Welsh, E.A., Liberton, M., Stöckel, J., Loh, T., Elvitigala, T., Wang, C., Wollam, A., Fulton, R.S., Clifton, S.W., Jacobs, J.M., Aurora, R., Ghosh, B.K., Sherman, L.A., Smith, R.D., Wilson, R.K., Pakrasi, H.B. (2008) Proc Natl Acad Sci USA 105:15094-15099.
"The Mammary Epithelial Cell Secretome and its Regulation by Signal Transduction Pathways." Jon M. Jacobs, Katrina M. Waters, Loel E. Kathmann, David G. Camp II, H. Steven Wiley, Richard D. Smith and Brian D. Thrall. (2008) J.Proteome Res. 7:558-569.
"Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset." Thomas O. Metz, Wei-Jun Qian, Jon M. Jacobs, Marina A. Gritsenko, Ronald J. Moore, Ashoka D. Polpitiya, Matthew E. Monroe, David G. Camp II, Patricia W. Mueller, and Richard D. Smith. (2008) J.Proteome Res. 7: 698-707.
"Profiling Signaling Polarity in Chemotactic Cells." Yingchun Wang, Shi-Jian Ding, Wei Wang, Jon M. Jacobs, Wei-Jun Qian, Ronald J. Moore, Feng Yang, David G. Camp II, Richard D. Smith, Richard L. Klemke. (2007) Proc Natl Acad Sci USA 104, 8328-8333.