Skip to Main Content U.S. Department of Energy
small banner

Jon Jacobs, Ph.D.


Jon Jacobs
Jon Jacobs

Dr. Jacobs' research expertise is in the application of proteomic technologies in the study of both prokaryotic and eukaryotic systems to obtain global quantitative measurements of protein abundance. Specifically, by using high efficiency liquid separations coupled with sensitive mass spectrometry, a more in-depth proteomic characterization of the model system can be obtained. Current applications include clinical proteomics with the study of cirrhosis progression using human liver biopsy samples from hepatitis C virus infected individuals as well as efforts to characterization protein secretion pathways by targeting the extracellular/secreted proteome of multiple human cell lines. In addition to being a Senior Scientist at PNNL, Dr. Jacobs also serves as an adjunct faculty member at Washington State University Tri-Cities.


  • Ph.D. , Biochemistry, Montana State University, 2002
  • B.S., Biochemistry, Brigham Young University, 1996

Selected Publications

Wegener KM, EA Welsh, LE Thornton, N Keren, JM Jacobs, KK Hixson, ME Monroe, DG Camp II, RD Smith, and HB Pakrasi. 2008. "High sensitivity proteomics assisted discovery of a novel operon involved in the assembly of photosystem II, a membrane protein complex."J Biol Chem. 283: 27829-27837.

Welsh EA, M Liberton, J Stöckel, T Loh, T Elvitigala, C Wang, A Wollam, RS Fulton, SW Clifton, JM Jacobs, R Aurora, BK Ghosh, LA Sherman, RD Smith, RK Wilson, and HB Pakrasi. 2008. "The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle." Proc Natl Acad Sci USA 105:15094-15099.

Jacobs JM, KM Waters, LE Kathmann, DG Camp II, HS Wiley, RD Smith, and BD Thrall. 2008. "The Mammary Epithelial Cell Secretome and its Regulation by Signal Transduction Pathways." J.Proteome Res. 7:558-569.

Metz TO, WJ Qian, JM Jacobs, MA Gritsenko, RJ Moore, AD Polpitiya, ME Monroe, DG Camp II, PW Mueller, and RD Smith. 2008. "Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset." J.Proteome Res. 7: 698-707.

Wang Y, SJ Ding, W Wang, JM Jacobs, WJ Qian, RJ Moore, F Yang, DG Camp II, RD Smith, and RL Klemke. 2007. "Profiling Signaling Polarity in Chemotactic Cells." Proc Natl Acad Sci USA 104, 8328-8333.

Contact Information

Systems Biology at PNNL

Research & Capabilities