Jon Jacobs, Ph.D.
Expertise
Jon Jacobs
Dr. Jacobs' research expertise is in the application of proteomic technologies in the study of both prokaryotic and eukaryotic systems to obtain global quantitative measurements of protein abundance. Specifically, by using high efficiency liquid separations coupled with sensitive mass spectrometry, a more in-depth proteomic characterization of the model system can be obtained. Current applications include clinical proteomics with the study of cirrhosis progression using human liver biopsy samples from hepatitis C virus infected individuals as well as efforts to characterization protein secretion pathways by targeting the extracellular/secreted proteome of multiple human cell lines. In addition to being a Senior Scientist at PNNL, Dr. Jacobs also serves as an adjunct faculty member at Washington State University Tri-Cities.
Education
- Ph.D. , Biochemistry, Montana State University, 2002
- B.S., Biochemistry, Brigham Young University, 1996
Selected Publications
Jacobs JM, Adkins JN, Qian WJ, Liu T, Shen Y, Camp DG, Smith RD. 2005. "Utilizing Human Blood Plasma for Proteomic Biomarker Discovery" J. Proteome Res. 4, 1073-1085.
Jacobs JM, Diamond DL, Chan EY, Gritsenko MA, Qian WJ, Stastna M, Baas T, Camp DG, Carithers RL, Smith RD, Katze MG. 2005. "Proteome Analysis of Liver Cells Expressing a Full- Length Hepatitis C Virus (HCV) Replicon and Biopsies of Post-Transplanted Liver from HCV-Infected Patients." J. Virol. 12, 7558-7569.
Qian WJ, Monroe ME, Liu T, Jacobs JM, Anderson GA, Shen Y, Camp DG II, Moore RJ, Anderson DJ, Zhang R, Davis RW, Tompkins RG, Smith RD. 2005. "Quantitative Proteome Analysis of Human Plasma Following in vivo Lipopolysaccharide Administration using 16O/18O Labeling and the Accurate Mass and Time Tag Approach" Mol. Cell. Proteomics 4, 700-709.
Jacobs JM, Monroe ME, Qian WJ, Shen Y, Anderson GA, Smith RD. 2005. "Ultra-sensitive, high throughput, and quantitative proteomic measurements." International Journal of Mass Spectrometry 240, 195-212.
Jacobs JM, Yang X, Luft BJ, Dunn JJ, Camp DG, Smith RD. 2005. "Proteomic Analysis of Lyme Disease: Global Protein Comparison of Three Strains of Borrelia Burgdorferi" Proteomics 5, 1446-1453.