Joshua N. Adkins, Ph.D.
Expertise
Joshua N. Adkins
Dr. Joshua Adkins has conducted scientific research in the areas of biochemistry, molecular biology, and proteomics. During his doctoral research he utilized bio-physical and enzymology-based methods to study the structure-function relationships between proteins central to the cell cycle of human cells, thus giving insights to the molecular nature of cancers.
Dr. Adkins began his research at the Pacific Northwest National Laboratory (PNNL) performing the first published proteomic analysis of blood serum using state of the art gel-free methods. He further authored and contributed to a number of key analyses performed under the Human Proteome Organization (HUPO) Plasma Proteome Project. This field has since expanded to search for clinical biomarkers. He has contributed to important PNNL and DOE initiatives in the proteomic analyses of model systems, including mouse models of emphysema and Shewanella protein-protein interactions. Additionally, Dr. Adkins's efforts have contributed to the development of methods of providing accessible data and results from large proteomic analyses to multidisciplinary research teams. Currently, he is offering project management assistance to Battelle Fellow, Richard Smith, on a contract from the National Institute of Allergy and Infectious Diseases NIH/DHHS studying host-pathogen interactions of the causative agent of "Typhoid Fever" and viruses closely related to Small Pox. Additional duties include the coordination and management of the Informatics and Bioinformatics Applications and Research Team under Richard Smith to develop advanced informatic methods to analyzing high-throughput proteomic results.
Education
- Ph.D., Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 2001
- B.S., Chemistry and Biology, Metropolitan State College of Denver, Denver, CO, 1995
Professional Societies
- The American Chemical Society
- Proteome Society
- American Society for Mass Spectrometry
Selected Publications
Adkins, J.N., Mottaz, H.M., Norbeck, A.D., Gustin, J., Rue, J., Clauss, T. RW., Purvine, S.O., Rodland, K., Heffron, F., Smith, R.D. Analysis of the Salmonella typhimurium Proteome during Environmental Adaptation to Infection-Mimicking Conditions. In revision: Mol. Cell. Proteomics.
Adkins, J. N., Monroe, M. E., Auberry, K. J., Shen, Y., Jacobs, J. M., Camp II, D. G., Moore, R. J., Rodland, K. D., Zangar, R. C., Smith, R. D., and Pounds, J. G. An accurate mass and time tag comparison of HUPO's pilot blood sera and citrated plasmas. Proteomics.5(13):3454-66 (2005).
Edberg, D.D., Adkins, J.N., Springer, D.L., and Reeves, R. Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteins. Journal of Biological Chemistry 280, 8961-8973 (2005).
Anderson, N. L., Polanski, M., Pieper, R., Gatlin, T., Tirumalai, R. S., Veenstra, T. D., Adkins, J. N., Pounds, J. G., Lobley, A., and Fagan, R. An Expanded Non-Redundant Human Plasma Proteome List Developed by Combination of Four Separate Sources. Molecular Cellular Proteomics 3, 311-326 (2004).
Adkins, J. N., Varnum, S. M., Auberry, K. J., Moore , R. J., Angell, N. H., Smith, R. D., Springer, D.L., and Pounds, J. G. Toward a Human Blood Serum Proteome I: Analysis by Multidimensional Separation Coupled with Mass Spectrometry. Molecular Cellular Proteomics 1, 947-955 (2002).