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Joshua N. Adkins, Ph.D.


Joshua N. Adkins
Joshua N. Adkins

Dr. Joshua Adkins' research centers on comprehensive characterization of proteins through space (associated proteins, structural determinants and localization) and time (before and after treatment, cell cycle, day-night cycle, and evolutionary changes) to better understand biological systems. Of particular interest to Dr. Adkins are challenging biological studies that require bridging the gaps between technology development and biological application. In recent years, this interest has led him to investigate host-pathogen interactions as model systems, ranging from studies of single pathogens, such as Salmonella to studies of host response, such as changes in lung fluid with viral infection. Currently, Dr. Adkins is Director for the Center for Systems Biology of EnteroPathogens. In this role, he leads a talented and multidisciplinary team comprised of scientists from PNNL, universities, and other research organizations whose aim is to develop therapeutics for the causative agents of Typhoid Fever and the Black Plague.


  • Ph.D., Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO (2001)
  • B.S., Chemistry and Biology, Metropolitan State College of Denver, Denver, CO (1995)

Professional Societies

  • American Chemical Society
  • Proteome Society
  • American Society for Mass Spectrometry

Selected Publications

Ansong C, H Yoon, S Porwollik, HM Mottaz-Brewer, B Petritis, N Jaitly, JN Adkins, M McClelland, F Heffron, and RD Smith. 2009." Global systems-level analysis of Hfq and Smpb deletion mutants in Salmonella: implications for virulence and global protein translation." PLoS ONE.

Chowdhury SM, L Shi, H Yoon, C Ansong, LM Rommereim, AD Norbeck, KJ Auberry, RJ Moore, JN Adkins, F Heffron, and RD Smith. 2009. "A method for investigating protein-protein interactions related to Salmonella Typhimurium pathogenesis." J Proteome Re.

Callister SJ, LA McCue, JE Turse, ME Monroe, KJ Auberry, RD Smith, JN Adkins, and MS Lipton. 2008. "Comparative bacterial proteomics: analysis of the core genome concept." PLoS One 3:e1542.

Gupta N, S Tanner, N Jaitly, JN Adkins, MS Lipton, R Edwards, MF Romine, A Osterman, V Bafna, RD Smith, and PA Pevzner. 2007. "Whole proteome analysis of post-translational modifications: applications of mass-spectrometry for proteogenomic annotation." Genome Res, 17:1362-1377.

Adkins JN, HM Mottaz, AD Norbeck, JK Gustin, J Rue, TRW Clauss, SO Purvine, KD Rodland, F Heffron, and RD Smith. 2006. "Analysis of the Salmonella typhimurium proteome through environmental response toward infectious conditions." Mol Cell Proteomics, 5:1450-1461.

Contact Information

Additional contact information.

Systems Biology at PNNL

Research & Capabilities