Print This PageEric J. Ackerman, Ph.D.
Expertise
Eric J. Ackerman
Cellular Observatory Research interests include molecular and structural mechanisms associated with DNA damage recognition/repair and signal transduction in eukaryotes. Develops model eukaryotic systems to serve as test systems for complex biological processes. Serves as the PNNL resource for identification, production, and purification of proteins via recombinant vehicles. He has authored 30 peer-reviewed publications.
Education
- Ph.D., Biophysics, University of Chicago, 1980
- Postdoc, Molecular Biology, MRC Lab of Molecular Biology, 1981-84
- B.S., Mathematics, University of Florida, 1975
Academic Appointments
1/81-7/84 Helen Hay Whitney Postdoctoral fellow, MRC Laboratory of Molecular Biology, Cambridge, England
7/84-1/85 Cancer Research Campaign Fellow, Cambridge University, Cambridge
1/85-3/85 Short-term Visiting Fellow, Freie University, Berlin
3/85-3/93 Senior Staff Fellow, NIDDK, NIH
3/93-8/96 Special Expert, NIDDK
8/96-present Staff Scientist, Molecular Biosciences Dept. and Environmental
Molecular Biosciences Dept., Pacific Northwest National Laboratory.
Honors/Fellowships
- B.S. with Highest Honors (Mathematics) University of Florida
- Anna Fuller Postdoctoral Fellowship (4 months) before activating Helen Hay Whitney Fellowship (3 years)
- Cancer Research Campaign Fellowship (6 months)
- Deutsche Akademischer Austauchdienst Fellow (short-term 6 week German fellowship)
- NIH Intraural AIDS Targeted Antiviral Program grant.
Selected Publications
Iakoucheva LM, RK Walker, B Van Houten, and EJ Ackerman. 2002. "Equilibrium and Stop-Flow Kinetic Studies of Fluorescently-Labeled DNA Substrates with DNA Repair Proteins XPA and Replication Protein A." Biochemistry 41(1):131-143.
Lei C, Y Shin, J Liu, and EJ Ackerman. 2002. "Entrapping enzymes in functionalized nanopores." Journal of the American Chemical Society.
Iakoucheva LM, AL Kimzey, CD Masselon, RD Smith, AK Dunker, and EJ Ackerman. 2001. "Aberrant mobility phenomena of the DNA repair protein XPA." Protein Science 10(7):1353-1362.
Kosmoski JV, EJ Ackerman, and MJ Smerdon. 2001. "DNA repair of a single UV photoproduct in a designed nucleosome." In Proceedings of the National Academy of Sciences of the United States of America 98(18):10113-10118.
Lavrik OI, R Prasad, RW Sobol, JK Horton, EJ Ackerman, and SH Wilson. 2001. "Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate." Journal of Biological Chemistry 276(27):25541-25548.
