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Integrated Data Structures for Mapping Cellular Networks

Ron Taylor, Principal Investigator

The Integrated Data Structures for Mapping Cellular Networks project is offering insight about the influence of environmental factors on cell function. As part of the project, researchers at Pacific Northwest National Laboratory (PNNL) are building the most comprehensive, multifaceted, RNA and protein database for a human cell line to date. This database centers on global cellular changes that occur in human mammary epithelial cells (HMEC) as they progress through their cell cycle. Recorded data include the genes and proteins expressed and their state of modifications throughout the cell cycle. A method is being developed to store, organize, and manage these large and divergent data sets, while providing the links to the bioinformatics and computational tools needed to interrogate the data and integrate results across multiple experiments and experimental approaches.

Using this tool, researchers will gain insight into cellular function at a systems level that cannot otherwise be gained by indirect comparison. Parameters under identical experimental conditions can be investigated, allowing researchers to understand the relationships at a more global scale. Results from this research will allow us to compare results from different experimental proteomic measurements (e.g., antibody versus mass spectrometry) to determine the limitations and biases each approach has in defining a proteomic state.

Systems Biology at PNNL

Research & Capabilities

Resources

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