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Proteomics

Whereas the genome is the potential of a biological system, the proteome is the realization of that potential. Researchers at Pacific Northwest National Laboratory (PNNL) undertake proteomics using a broad range of techniques in a variety of systems and continue to develop and refine new methods and technologies that strengthen PNNL’s capabilities in this burgeoning area of research. Our technological approach to proteomics is multifaceted.

• PNNL’s high-field mass spectrometry capability provides high sensitivity and accuracy and includes a novel accurate mass tag approach.
• Our researchers generate synthetic antibodies for use as molecular reagents in fundamental biology studies and for developing biosensor technologies.
• We develop high-throughput, high-sensitivity proteomic assays.
• The strong computational biology capability at PNNL facilitates proteomic data interpretation and modeling.

PNNL’s proteomic facilities are extensive. Our mass spectrometry instruments are housed in a central location in the High Perfomance Mass Spectrometry (HPMS) Facility, which is part of the William R. Wiley Environmental Molecular Science Laboratory (EMSL).

Through funding from the National Institutes of Health we built the Proteomics Research Resource for Integrative Biology, a national user facility established to serve the biomedical research community.

PNNL also participates in the U.S. Department of Energy Office of Science Genomics:GTL (Genomes to Life) program. Our world-class, high-field mass spectrometry capabilities are integral to PNNL’s Genomics:GTL Research projects and align with the needs of the DOE GTL program and planned user facilities.

Simulation of PNNL protein identification process featured in journal special edition. View highlight (PDF, 79K).