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Advanced Cell and Molecular Imaging

Most analytical techniques in biology provide information on populations of cells. However, to fully understand and model the behavior of biological systems, processes must be understood at the level of individual cells. Imaging technologies offer a powerful approach for observing and quantifying biochemical processes in living cells and bridge the gap between system and molecular-level studies.

To fully understand the behavior of biological systems, researchers at Pacific Northwest National Laboratory (PNNL) have developed a wide range of imaging technologies to probe biochemical processes using both living and fixed cells. Our advanced instrumentation produces images at a wide variety of scales, revealing information from the macroscopic to the molecular level. Traditional microscopes analyze samples using a single imaging modality, usually with a single wavelength of light. We are building advanced instruments that combine the capabilities of multiple instruments, allowing different dimensions of information to be gathered simultaneously. We are also developing advanced algorithms to extract quantitative data from multispectral images.

Advances in microscopy require not only the development of more sensitive and specific instruments, but also the creation of software to operate the instruments and manage the large amounts of data they can generate. Scientists at PNNL are currently building the data infrastructure for storage, access, processing, and analysis of imaging data with the goal of turning advanced cell imaging into routine laboratory techniques.

Advanced Cell and Molecular Imaging, poster.
Download Advanced Cell and Molecular Imaging poster (PDF, 166KB).

Systems Biology at PNNL

Research & Capabilities

Resources

Cell Imaging Tools

Applying Capabilities to Research

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